Knockouts of Vlgr1 in mice have been shown to phenocopy Usher's syndrome and lead to audiogenic seizures.
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Additionally, overexpression of sulfatide has been linked to epilepsy and audiogenic seizures as well as other pathological states in the nervous system.
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Elevated levels of sulfatide have also been linked to epilepsy and audiogenic seizures ( seizures induced by sound ), while elevated levels of anti-sulfatide antibodies in the serum have been associated with multiple sclerosis and Parkinson's.
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